Choose the best answer.
1. The most common cause of nephrotic syndrome in paediatrics population is
A) Minimal change disease
B) Mesangial proliferation
C) Focal segmental glomerulosclerosis
D) Membranous nephropathy
E) membranoproliferative glomerulonephritis
2. Below are the characteristic features of nephrotic syndrome EXCEPT
A) Proteinuria more than 40mg/m2/hour
B) Hypoalbuminaemia
C) gross haematuria
D) Oedema
E) Hyperlipidaemia
True/false questions.
3. In Minimal change disease
A) gromeruli appear normal on light microscopy
B) Immunofluorescence microscopy show IgM and C3 staining.
C) Most children will response to corticosteroids treatment
D) Renal biopsy is indicated to confirm diagnosis before starting treatment
E) Most children will have end stage renal failure
4. Features that make minimal change disease less likely includes
A) Less than 1 year old at presentation
B) Hematuria
C) Hypertension
D) Renal insufficiency
E) Hypocomplementemia
5. Focal segmented glomerulosclerosis
A) Account for 10% of children with idiopathic nephrotic syndrome
B) Immunofluorescence microscopy show IgM and C3 staining.
C) Most children will response to corticosteroids treatment.
D) Most children will have end stage renal failure.
E) Light microscopy show mesangial proliferation and segmental scaring.
6. Management of idiopathic nephrotic syndrome
A) Low sodium diet play a role
B) Fluid restriction may be necessary
C) Diuretic use is associated with decrease risk of thromboembolic complication
D) with presumed minimal change disease, prednisone is administered for 5 days.
E) cyclophosphamide can be used in patient with steroid resistant disease.
Written by CH LEE on 5/1/2008
About my MCQ.
Please give suggestions and update to this question. Click on comments below for answer.
exblog2012.wordpress.com 
1. A
2. C
3.
A) True.
B) False. Immunofluorescence microscopy is typically negative in minimal change disease. Positive IgM and C3 in focal segmental glomeruloslerosis
C) True. 95% will response to corticosteroids treatment
D) False. Patient with typical feature of minimal change disease do not need renal biopsy.
E) False. Prognosis is good.
4. Answer: All True
Also presentation older than 8 year old
5.
A) True.
B) True.
C) False. 20% response to corticosteroids treatment.
D) True.
E) True
6.
A) True.
B) True.
C) False. Diuretic increase risk of thromboembolic event.
D) Flase. Prednisone for a minimal of 4 weeks.
E) True.
E) True.
In Q-4 (b) In minimal change glomerulla disease is likely to have hematuria compairing to non minimal. There for it is FALSE.
If I am wrong plz correct me 🙂
Thank U
Having haematuria make minimal change disease less likely. The answer provided by the author (LCHXIAN) is correct. Question 4 all true.
Good exercise for medical students:)
I did badly in my MCQ papers,coz it’s negative marking,so sometimes guessing the answer is not a wise choice:( I read textbooks but the pro is the memory:)
Anyway,thanks for posting up these useful MCQ,Bro Cheng Hiang:)
No problem:)
Btw, IMU still having negative marking? Is the passing mark still 65%?
I remember very well how painful negative marking can be…
the phase 1 in Bukit Jalil has no negative marking,but in seremban clinical sch,this cruel marking system exist,and kill a lot of ppl:(
Hai hai,esp peads( i see the very scary result graph in sem 9 seniors notice board…scary!!!)
For those looking, more useful medical information about nephrotic syndrome can be found nephrotic syndrome
Good for exercise. Thanks.
thanks a lot 🙂
Thank you very much.This has made me to understand my module better.
No problem. Do drop by again.
I am final year student of Mbbs, i read your mcqs it remind me what i have left n my stdy .very nice
thanks , but i ask more mcqs