Genetic Pedigree MCQ

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Pokemon deficiency is a rare autosomal recessive disorder presenting in infancy. 1 in 250,000 people is affected. Heterozygous carrier are not affected and have a normal blood biochemistry.

The proband (IV,3) was diagnosed to have Pokemon deficiency at 6 months of age. Her newborn younger brother was also diagnosed with the same disease.

Pokemon Deficiency

Pokemon Deficiency

1. What is the probability of her 15 year old brother (IV,2) being a carrier?

    A) 1 in 2

    B) 1 in 4

    C) 2 in 3

    D) 1 in 3

    E) 0

    2. What is the probability of her mother (III,4) being a carrier.

    A) 1

    B) 1 in 2

    C) 1 in 250,000

    D) 0

    E) Not possible to calculate.

    3. What is the probability of individual III,2 being a carrier?

    A) 1 in 8

    B) 1 in 16

    C) 1 in 2

    D) 1 in 4

    E) 1 in 250 000

    4. If the population were in Hardy-Weinberg equilibrium, what is the carrier frequency in the population?

    A) 1 in 250 000

    B) 1 in 250

    C) 1 in 5000

    D) 1 in 1000

    E) 1 in 100

    5. What is the probability of the offspring of individual III,2 have Pokemon deficiency, if there is no consanguinity?

    A) 1 in 1000

    B) 1 in 250 000

    C) 1 in 4

    D) 1 in 256

    E) 1 in 16000

    6. If individual III,2 and III,1 were to produce a male  offspring. What is the probability of him being affected?

    A) 1in 4

    B) 1 in 64

    C) 1in 16

    D) 1 in 5000

    E) 1 in 128

Written by CH LEE on 20/12/2008

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Australian Snake Bite MCQ

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A child was bitten by  a Brown Snake (Pseudonaja textilis) in Australia. What is the most common clinical problem associated with Brown Snake envenomation?
A. Coagulopathy

B. Neurotoxicity

C. Nephrotoxicity

D. Myotoxicity

E. Brown snake is non venomous.

Written by CH LEE on 9/12/2008

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